Table 2.
Patient code | Origin | Treatment | Subtype in PR gene |
Protease inhibitor resistance mutations |
Subtype in RT gene |
RT inhibitor resistance mutations |
---|---|---|---|---|---|---|
SE58 | EE | HAART | A | M36I, V77I | N.D. | N.D. |
SE115 | CSA | Naive | B | M36I | C | None |
SE71 | CSA | HAART | C | M36I | C | V118I |
SE73 | EE | Naive | F | L10V, K20R, M36I | F | None |
SE43 | CSA | HAART | F | M36I | B | None |
SE99 | EE | Naive | F | K20R, M36I | F | None |
SE108 | CSA | Naive | F | K20R, M36I | F | None |
SE37 | SSA | Naive | G | K20I, M36I | G | K70R, A98G |
SE103 | SSA | Naive | G | K20I, M36I | G | None |
SE31 | SSA | Naive | J | K20I, M36I, V77I | J | None |
SE91 | SSA | Naive | K | M36I, L63P | G | E138A |
SE11 | SSA | HAART | CRF02_AG | K20I, M36I, L63P | G | None |
SE16 | SSA | TI | CRF02_AG | K20I, M36I | G | None |
SE113 | N.D. | Naive | CRF02_AG | K20I, M36I | G | None |
SE66 | WE | HAART | CRF02_AG | K20I, M36I | CRF02_AG | None |
SE59 | NAF | HAART | CRF02_AG | K20I, M36I, L90M | CRF02_AG | None |
SE67 | SSA | HAART | CRF02_AG | K20I, M36I, L63P | CRF02_AG | None |
SE49 | SSA | Naive | CRF02_AG | K20I, M36I, L63P | CRF02_AG | None |
SE50 | SSA | TI | CRF02_AG | K20I, M36I, L63P, V77I | CRF02_AG | None |
SE33 | SSA | TI | CRF02_AG | L10V, K20I, M36I | CRF02_AG | None |
SE36 | CSA | HAART | CRF02_AG | K20I, M36I | CRF02_AG | None |
SE101 | SSA | Naive | CRF02_AG | K20I, M36I | CRF02_AG | None |
SE110 | EE | Naive | CRF02_AG | K20I, M36I | CRF02_AG | None |
SE111 | SSA | HAART | CRF02_AG | K20I, M36I | CRF02_AG | 90I |
SE34 | SSA | TI | CRF02_AG | K20I, M36I | CRF01_AE | L100I |
SE96 | SSA | Naive | CRF02_AG | K20I, M36I | CRF02_AG | None |
SE62 | EE | Naive | CRF01_AE | M36I | CRF01_AE | None |
SE60 | EE | HAART | CRF01_AE | M36I | CRF01_AE | K103N |
SE19 | SSA | HAART | N.D | N.D. | CRF02_AG | None |
Protease and RT inhibitor resistance mutations.
CSA, Central-South America; SSA, Sub-Sahara Africa; EE, Eastern Europe; WE, Western Europe; NAF, Northern Africa. HAART, Highly Active Antiretroviral Therapy. TI, treatment interruption. Bold, major resistance. N.D., not determined.