Figure 4. Meta-analysis of CNI minimization versus routine CNI regimen in CrCl (RCTs).
In MMF, sirolimus and everolimus subgroup, the improvement of CrCl over routine CNI regimen group was not statistically significant, as well as in the total 10 RCTs. Z = total effect size, I2 = heterogeneity index. Columns in green represent the mean difference of each study and column size represents the study weight in the analysis. Lanes represent the 95% CI of each study. Diamonds in black represent the overall effect size and diamond width represents the overall 95% CI.