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. 2000 Nov 1;14(21):2712–2724. doi: 10.1101/gad.835000

Figure 1.

Figure 1

Comparison of Drosophila and human TOR proteins. The ClustalW 1.8 algorithm was used to align the amino acid sequences of dTOR and human mTOR/FRAP (GenBank accession no. 744518). Dark boxes indicate identical amino acids; gray boxes indicate similarity. The conserved FKBP12–rapamycin-binding domain (amino acids 2025–2114 in mTOR; Vilella-Bach et al. 1999) is underlined, and the essential serine in this domain is indicated by an asterisk. Sites of mTOR autophosphorylation (Ser-2481) and phosphorylation by Akt/PKB (Ser-2448) are marked with carats.