Table 4.
Top ranking miRNA clusters with interconnected target sets
| miRNA cluster15,* | # targ | Ppis [#| P-value] | Ppis [miR-miR] [# |P-value] | ||
|---|---|---|---|---|---|
| hsa-miR-3671-101 | 116 | 94 | 0.1294 | 94 | 0 |
| hsa-let-7a-7b | 120 | 48 | 0.1748 | 48 | 0 |
| hsa-miR-1912-1264 | 49 | 24 | 0.3224 | 24 | 0 |
| hsa-miR-214-199a | 69 | 22 | 0.3222 | 22 | 0 |
| hsa-miR-296-298 | 52 | 24 | 0.3324 | 24 | 0 |
| hsa-miR-105-767 | 58 | 18 | 0.3418 | 18 | 0 |
| hsa-miR-34b-34c | 43 | 22 | 0.3522 | 22 | 0 |
| hsa-miR-3677-940 | 55 | 18 | 0.3618 | 18 | 0 |
| hsa-miR-1914-647 | 38 | 20 | 0.3720 | 20 | 0 |
| hsa-miR-599-875 | 23 | 6 | 0.536 | 6 | 0 |
| hsa-miR-16-15a | 172 | 172 | 0.12172 | 172 | 0 |
| hsa-miR-15b-16 | 172 | 172 | 0.15172 | 172 | 0 |
| hsa-miR-181c-181d | 160 | 142 | 0.21142 | 142 | 0 |
| hsa-miR-195-497 | 172 | 172 | 0.15172 | 172 | 0 |
| hsa-miR-181a-181b | 160 | 142 | 0.19142 | 142 | 0 |
| hsa-miR-181b-181a | 160 | 142 | 0.18142 | 142 | 0.01 |
| hsa-miR-30e-30c | 183 | 144 | 0.2144 | 144 | 0.01 |
| hsa-miR-513c-513b | 125 | 142 | 0.21142 | 142 | 0.01 |
| hsa-miR-23b-24 | 305 | 584 | 0.02234 | 234 | 0.01 |
| hsa-miR-363-106a | 341 | 550 | 0.29823 | 823 | 0.01 |
| hsa-miR-200c-141 | 246 | 392 | 0.02112 | 112 | 0.01 |
| hsa-miR-30b-30d | 183 | 144 | 0.2144 | 144 | 0.01 |
| hsa-miR-519a-1283 | 298 | 702 | 0.02258 | 258 | 0.01 |
| hsa-miR-24-23a | 305 | 584 | 0.03234 | 234 | 0.02 |
| hsa-miR-522-1283 | 323 | 864 | 0.02377 | 377 | 0.02 |
| hsa-miR-25-106b | 233 | 236 | 0.22224 | 224 | 0.02 |
| hsa-miR-301b-130b | 123 | 86 | 0.3486 | 86 | 0.03 |
| hsa-miR-182-183 | 218 | 288 | 0.15196 | 196 | 0.03 |
| hsa-miR-17-92a | 341 | 550 | 0.28607 | 607 | 0.03 |
| hsa-miR-133a-1 | 189 | 262 | 0.0574 | 74 | 0.03 |
| hsa-miR-545-374a | 180 | 212 | 0.0862 | 62 | 0.04 |
| hsa-miR-206-133b | 189 | 262 | 0.0774 | 74 | 0.04 |
| hsa-miR-29a-29b | 126 | 64 | 0.3864 | 64 | 0.05 |
| hsa-miR-513a-508 | 242 | 256 | 0.0559 | 59 | 0.05 |
| hsa-miR-513a-507 | 242 | 256 | 0.0559 | 59 | 0.05 |
*miRNA cluster is termed in the following way: miR-first_miRNA-last_miRNA. For instance, miR-17-92a cluster is consisted of six miRNAs, miR-17 is the first miRNA in the cluster and miR-92a is the last miRNA in the cluster.
Interconnectivity of the target sets was evaluated as: (1) Number of interactions in the union target set and (2) Number of interactions between target sets of all distinct miRNA pairs in a cluster (ppis [miR-miR]). The P-values were estimated by comparing the observed value with 1,000 randomly sampled target sets of equal size. The results for all clusters are shown in Additional file 7, Table S7 online.