Table 3. Size measurement of liposome formulation (varying d/l mole ratio) during storage at 4°C and after in vitro drug release in PBS buffer (pH 7.4) at 37°C.
| Size measurement, nm (PDI) | ||||||
| Latanoprost/DPPC Liposome (actual) drug/lipid mole ratio) | W0 | W2 | W4 | W8 | W16 | After in vitro drug release |
| 0.00 | 82(0.05) | 93(0.06) | ---- | 91(0.06) | 92(0.06) | 93(0.06) |
| 0.04 | 86(0.05) | 89 | 102(0.06) | 104(0.06) | 104(0.06) | 110(0.06) |
| 0.07 | 111(0.07) | 89(0.06) | 98(0.06) | 100(0.06) | ---- | ---- |
| 0.10 | 109(0.08) | 105(0.10) | 105(0.10) | ---- | 110(0.10) | 150(0.1) |
| 0.14 | 78(0.06) | 93(0.06) | 93(0.08) | 101(0.08) | 117(0.10) | 145(0.12) |
| 0.18 | 194(0.10) | 210(0.10) | 210(0.10) | — | 310(0.20) | 442(0.20) |
| 0.37 | 118(0.10) | 93(0.10) | 93(0.20) | 1015(0.3) | 1176(0.30) | 2020(0.80) |