Table 1.

Baseline characteristics of subjects with metastatic and benign pheochromocytoma

Parameter	Metastatic pheochromocytoma (n=41)	Benign pheochromocytoma (n=108)	P
Gender (male/female)	19/22	44/62	NS
Age (years) (min; max)	41.4±14.7 (6;83)	50.2±13.7 (21;78)	<0.001
Age <40 years (%)	19 (46.3%)	26 (24.1%)	0.008
Tumor dimension (cm) (min; max)	8.38±3.27 (2.4;17)	6.18±2.75 (2;16)	<0.001
Number of tumors ≥5cm	37 (90%)	72 (66.7%)	0.002
Right adrenal	28 (68.3%)	59 (54.6%)	0.11
Left adrenal	12 (29.3%)	44 (40.7%)	NS
Bilateral adrenal involvement	4 (9.8%)	5 (4.6%)	NS
Syndromic presentation	9 (25.7%)	11 (14.7%)	0.13
SDHB	2	0
MEN 2	4	2
VHL	3	5
NF1	0	4

SDHB, succinate dehydrogenase subunit B; MEN 2, multiple endocrine neoplasia type 2; VHL, von Hippel-Lindau; NF1, neurofibromatosis type 1; NS, non-significant.