Scheme 13.
Endgame for (−)-4,8,10-tridesmethyl telithromycin (3).a
a Reagents and conditions: (a) NaH, CDI, THF/DMF then 6, 35%; (b) TASF, DMF/H2O, 70%; (c) NCS, DMS, Et3N; (d) MeOH, 45% over two steps.
Endgame for (−)-4,8,10-tridesmethyl telithromycin (3).a
a Reagents and conditions: (a) NaH, CDI, THF/DMF then 6, 35%; (b) TASF, DMF/H2O, 70%; (c) NCS, DMS, Et3N; (d) MeOH, 45% over two steps.