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. Author manuscript; available in PMC: 2012 Sep 30.
Published in final edited form as: Respir Physiol Neurobiol. 2011 May 10;178(3):406–413. doi: 10.1016/j.resp.2011.05.003

Table 1.

Published effects of various oxidants on TRPA1, TRPV1 and P2X2 channels. Data comes from ion channel overexpression in cell lines (e.g. HEK293 and CHO cells). N.D., not determined. See references for more details.

TRPA1 TRPV1 P2X2
Superoxide (O2−) EC50 333μM (Sawada et al., 2008) N.D. N.D.
Hydrogen Peroxide (H2O2) EC50 23μM (Takahashi et al., 2008)
EC50 200μM (Sawada et al., 2008)
EC50 230μM (Andersson et al., 2008)		 No effect < 10mM (Andersson et al., 2008)
Activation with 10mM (Susankova et al., 2006)
Activation with 1mM (Chuang and Lin, 2009)		 Potentiation with 300μM (Coddou et al., 2009)
Inhibition IC50730 μM (Mason et al., 2004)
Ozone (O3) EC50 3μM (Taylor-Clark and Undem, 2010) No effect < 30 μM (Taylor-Clark and Undem, 2010) N.D.
Hypochlorite (OCl−) EC50 11ppm (Bessac et al., 2008) N.D. N.D.
Chloramine-T EC50 11μM (Bessac et al., 2008) Activation with 1mM (Susankova et al., 2006) N.D.
Toluene diisocyanate EC50 10μM (Taylor-Clark et al., 2009) No effect < 100μM (Taylor-Clark et al., 2009) N.D.
Methyl isocyanate EC50 25μM (Bessac et al., 2009) No effect < 100μM (Bessac et al., 2009) N.D.
Hexamethylene diisocyanate EC50 2.6μM (Bessac et al., 2009) No effect < 100μM (Bessac et al., 2009) N.D.
Acrolein EC50 5μM (Bautista et al., 2006)
EC50 0.8μM (Andre et al., 2008)		 No effect < 100μM (Bautista et al., 2006)
No effect < 1mM (Dinis et al., 2004)		 N.D.
4-hydroxy-2- nonenal EC50 27μM (Trevisani et al., 2007)
EC50 13μM (Macpherson et al., 2007b)
EC50 20μM (Andersson et al., 2008)
EC50 10μM (Taylor-Clark et al., 2008a)		 No effect < 500μM (Macpherson et al., 2007b)
No effect < 100uM (Andersson et al., 2008)		 N.D.
4-oxo-2-nonenal EC50 1.9μM (Andersson et al., 2008)
EC50 1.6μM (Taylor-Clark et al., 2008a)		 Activation with 100μM (Taylor-Clark et al., 2008a) N.D.
Crotoaldehyde EC50 23μM (Andre et al., 2008) N.D. N.D.
Formaldehyde EC50 200μM (McNamara et al., 2007),
EC 50 357μM (Macpherson et al., 2007b)		 No effect seen < 1mM (Macpherson et al., 2007b)
No effect seen < 1.25mM (McNamara et al., 2007)		 N.D.
Particulate Matter (PC10) N.D. Activation with 1 particle (Agopyan et al., 2003a) N.D.
Particulate Matter (PC2) N.D. Activation with 4 particles (Agopyan et al., 2003a) N.D.
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