Evidence of early lung injury 48 h after intratracheal instillation of 3 units of bleomycin.
A: Representative histology sections (hematoxylin and eosin staining) of a control and lung-injured rat lungs.
B: Breathing patterns at baseline (Top panels) and 48 h after Bleomycin (black traces) or saline (gray traces, bottom panels).
C: Bronchoalveolar lavage fluid (BALF) analysis identifies cellular inflammation and elevated protein suggestive of damage to the alveolar-capillary interface. *p<0.001.