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. 2011 May 5;28(10):2393–2402. doi: 10.1007/s11095-011-0451-4

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© The Author(s) 2011

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Fig. 4 — Immunogenicity of untreated, metal-catalyzed-oxidized (MCO), hydrogen-peroxide-treated (H₂O₂) and guanidine-treated (Guanidine) rhIFNβ-1a in (a) wild-type and (b) transgenic mice. Bars show BAB titers of total IgG against rhIFNβ as determined by ELISA at day 21 for each individual mouse injected daily, from Monday to Friday, i.p. for 3 weeks. Non-responders were given a titer of 10. Statistical analyses (Kruskal-Wallis non-parametric one-way ANOVA with Dunn’s multiple comparison test) were performed comparing the titers of each treatment group with the titers of mice injected with untreated rhIFNβ-1a. Treatment groups that differ significantly (p < 0.05) from the mice injected with untreated rhIFNβ-1a are indicated.