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Number of Wild-Type and Transgenic Mice Out of the Total Number of Mice Per Treatment Group Showing Neutralizing Antibodies Against rhIFNβ at Day 21. Six Out of 80 Mice Died During the Study Due to Handling or Other Reasons, Such as Liver or Heart Problems
| Wildtype | Transgenic | |
|---|---|---|
| Untreated rhIFNβ-1a | 7/8 | 0/10 |
| Metal-catalyzed-oxidized rhIFNβ-1a | 6/9 | 0/9 |
| H2O2-treated rhIFNβ-1a | 9/10 | 1/9 |
| Guanidine-treated rhIFNβ-1a | 9/10 | 0/9 |
