Fig. 5.

Simulated drug concentration-time profiles for perturbations in different pharmacodynamic parameters at the 3 mg/kg dose level. The values were perturbed 5- and 10-fold at the higher and lower end of the base value. The fold variations are denoted by numerals corresponding to the extent of variation. The perturbations at the lower end of the base parameter values are denoted by the letter L and at the higher end by the letter G. For example, L10 indicates a value 10-fold lower than the base value of the parameter. This nomenclature is adapted from reference 43.