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. 2011 Jun 7;28(10):2490–2504. doi: 10.1007/s11095-011-0477-7

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© The Author(s) 2011

This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

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Fig. 7 — Predictive check of the PBPKPD model for D₂RO after olanzapine administration, at 3 mg/kg dose. A number of 1,000 data sets were simulated from the final PBPKPD parameter estimates. Depicted are the observed D₂RO (dots) and the shaded area represents the upper (95%) and lower (5%) quantile of the simulated D₂RO. Median of the simulated D₂RO are represented as solid line; median of the observed D₂RO are represented as dashed line.