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. Author manuscript; available in PMC: 2012 Sep 8.
Published in final edited form as: Neuron. 2011 Sep 8;71(5):858–868. doi: 10.1016/j.neuron.2011.06.035

Figure 6. Increased innervation of D2 MSNs by fast-spiking interneurons promotes synchrony in a model of the striatal circuit.

Figure 6

A. Diagram of synaptic connections in the model and the connection probability of each. Loops indicate lateral connections onto the same MSN subtype, not autapses. The conductance of all FS synapses was set to 1 nS and the conductance of all MSN synapses was set to 0.2 nS. B. Raster plot showing the firing of each neuron in the control network in response to input, simulated by a Gaussian noise function with a standard deviation of 100 pA. C. Normalized average cross-correlogram for the population of D1 MSNs and D2 MSNs. The normalized cross-correlogram was computed from data rebinned into 5 ms and converted to a z-score. D. Raster plot showing the firing of each neuron in the dopamine-depleted network in response to input, simulated by a Gaussian noise function with a standard deviation of 100 pA. E. Normalized average cross-correlogram for the population of D1 and D2 MSNs. Data was binned into 5 ms bins and converted to a z-score. Note the marked increased in synchrony apparent in the population of D2 MSNs.