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. 2011 Aug 29;134(9):2627–2641. doi: 10.1093/brain/awr193

Figure 2.

Figure 2

Motoneuron survival after 14 days of co-culture with SOD1G93A (Tg) or NTg astrocytes (n = 3, each n is a triplicate, bars = SD, one-way ANOVA plus Tukey's multiple comparison test). Results were normalized to motoneuron survival grown on NTg astrocytes without lactate treatment. Statistical analysis was performed comparing all groups to motoneuron survival on SOD1G93A (significance = #; where ## = <0.01; ###= <0.001) or NTg (significance =*; where *= <0.05; **= <0.01) astrocytes under basal conditions. SOD1G93A astrocytes increase motoneuron death by 38% (**P < 0.01) compared with NTg astrocytes under basal conditions. The addition of 0.5 mM lactate has no effect, while 1 mM lactate completely rescues motoneuron viability on SOD1G93A astrocytes. Lactate (2 mM) concentration improves motoneuron survival on SOD1G93A astrocytes compared with motoneuron survival on NTg astrocytes untreated (**P < 0.01). NTg = non-transgenic; Tg = transgenic.