Table 3.

Grey and white matter regions predominantly involved in voxel-based morphometry analysis of FTLD pathologies

	Grey matter												White matter
	Frontal			Temporal					Parietal		Subcortical
	dFL	ACC	OFC	sTL/Ins	TP	mTL	iTL	pTL	PCC/PC	LPL	BG	Thal	SLF	ILF	UF	CC	Fornix	Brainstem
Pick’s disease	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+	+
MAPT mutations			+	+	+	+	+							+			+
Corticobasal degeneration	+	+		+				+	+	+	+		+	+
TDP-A	+	+	+	+	+	+	+	+	+	+	+	+	+	+		+		+
TDP-C		+	+	+	+	+	+	+						+	+		+
FUS			+	+							+

Involved regions (coded +) are based on the contrast between the disease group and healthy control subjects, at a voxel-wise significance threshold P < 0.01 corrected over the whole brain volume.

ACC = anterior cingulate cortex; BG = basal ganglia; CC = corpus callosum; dFL = dorsolateral frontal lobe; ILF = inferior longitudinal fasciculus; iTL = inferior temporal lobe; Ins = insula; LPL = lateral parietal lobe; MAPT = microtubule-associated protein tau; mTL = medial temporal lobe; OFC = orbitofrontal cortex; PC = precuneus; PCC = posterior cingulate cortex; pTL = posterior temporal lobe; SLF = superior longitudinal fasciculus; sTL = superior temporal lobe; TDP-A = TAR-DNA-binding protein-43 type A pathology; TDP-C = TAR-DNA-binding protein-43 type C pathology; Thal = thalamus; TP = temporal pole; UF = uncinate fasciculus.