Skip to main content
. 2000 Nov 15;14(22):2819–2830. doi: 10.1101/gad.844900

Figure 1.

Figure 1

Effect of dietary cholesterol on the liver expression of SREBPs and lipogenic enzymes in wild-type and Lxr-knockout mice. Mixed strain (A129/C57Bl6) male mice of various Lxr genotypes were fed basal (0.02% cholesterol) or high cholesterol (2% cholesterol) diets for seven days. Liver mRNA was pooled from six animals per treatment group and Northern analysis performed using probes for SREBP-1 and -2, SCD-1, FAS, and ACC (Shimano et al. 1996). All RNA levels are expressed relative to wild-type mice on basal diet. Numbers above bars refer to relative fold changes in mRNA levels between animals of the same genotype after high cholesterol feeding. Genotypes denoted are: wild-type (WT); Lxrα−/− (α−/−); Lxrβ−/− (β−/−); and Lxrα/β−/− (α/β−/−).