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A through D, SU6656 or toxin B almost completely inhibits macrophage macropinosome formation. Macrophages were treated for 5 hours without SU6656 (A) or with 20 µmol/L SU6656 (B) or for 5 hours without toxin B (C) or with 100 ng/mL toxin B (D) and imaged by phase-contrast microscopy. The macropinosome vacuoles were substantially decreased in cultures with added inhibitor. The bar indicates 50 µm.
