Table 2.

Clinical information, morphology, immunophenotype, EBER in situ hybridization, and TCR gene rearrangement of extranodal NK/T-cell lymphoma, nasal type of head and neck region*

No.	Age/Sex	Site (s) of involvement	Symptom (s) and its duration	Basic morphology	CD3	CD5	CD7	CD4	CD8	βF1	CD56	TIA1	GB	PF	CD45	CD30	EBER	TCR gene	Clinical course
1	74/M	Nasal cavity	Rhinorrhea, 1 year	large (A+, N+)	+	-	-	-	-	-	+	+	+	+	+	+	+	I	D, 3 mos
2	40/M	Nasal cavity	Nasal obstruction, 3 mos	medium (A+, N+)	p+	-	-	-	-	-	-	+	p+	p+	-	+	+	I	D, 33 mos
3	31/M	Nasal cavity	Nasal obstruction, 1 mo	large (A+, N+)	p+	-	-	-	-	-	+	+	+	+	+	+	+	-	D, 37 mos
4	37/M	Nasal cavity	Orbital cellulitis, and fever, 2 mos	medium (A-, N+)	p+	-	-	-	-	-	p-	+	p+	+	NA	+	+	-	D, 3 mos
5	41/F	Nasal cavity	Nasal obstruction, 1 mo	small to medium (A+, N+)	+	-	NA	-	-	-	+	+	p+	+	+	NA	+	-	D, 3 mos
6	49/F	Nasal cavity	Nasal obstruction, 2 mos	medium to large (A-, N+)	+	-	+	-	-	-	+	+	+	+	+	p+	+	-	A, 60 mos
7	43/F	Nasal cavity	Nasal obstruction, 2 mos	medium to large (A+, N+)	p+	-	-	p+	-	-	+	+	+	+	-	p+	+	-	D, 8 mos
8	32/M	Nasal cavity	Nasal obstruction, 5 mos	medium to large (A-, N+)	+	-	p-	-	-	-	+	+	p+	p+	NA	-	+	-	D, 3 mos
9	33/M	Nasal cavity	Rhinorrhea, 1 mo	medium (A+, N+)	+	-	+	-	-	-	+	+	p-	p-	p+	+	+	-	D, 4 mos
10	38/M	Nasal cavity	Nasal obstruction with epistaxis, 2 yrs	medium (A+, N+)	+	-	-	-	-	-	p+	+	+	+	+	+	+	I	D, 7 mos
11	48/F	Nasal and oral cavities	Nasal obstruction, 1 mos	medium to large (A+, N+)	+	p+	NA	-	-	-	p+	+	p+	p+	NA	-	+	-	D, 3 mos
12	36/M	Nasal cavity and nasopharynx	Epistaxis with fever, 1 mo	small to medium (A+, N+)	+	-	+	-	-	-	+	+	p+	p-	p+	-	+	-	D, 1 mos
13	26/F	Nasal cavity and nasopharynx	Rhinorrhea, 2 mos	medium (A+, N+)	+	p+	+	-	-	-	+	+	+	+	NA	-	+	-	D, 4 mos
14	42/M	Nasal cavity and nasopharynx	Epistaxis (HIV+), 2 mos	medium to large (A-, N+)	+	-	-	p+	-	-	+	+	+	+	p+	p+	+	-	D, 18 mos
15	41/M	Nasopharynx	Dysphagia, 3 mos	medium (A+, N-)	+	-	-	-	-	-	p+	+	+	+	+	+	+	-	D, 11 mos
16	44/M	Nasopharynx	Rhinorrhea with epistaxis, 6 mos	medium to large (A+, N+)	-	-	-	-	-	-	-	+	p+	-	-	+	+	-	D, 2 mos
17	42/M	Nasopharynx	Nasal obstruction, 1 wk	medium to large (A+, N+)	+	-	+	-	-	-	+	+	+	+	p+	+	+	I	D, 5 mos
18	57/F	Oral cavity	Palatal mass, 2 mos	large (A+, N+)	+	-	-	-	-	-	+	+	+	+	p+	-	+	-	D, 4 mos
19	38/M	Oral cavity	Chronic oral ulcer, 3 mos	medium to large (A-, N+)	+	-	-	-	-	-	-	+	+	p+	+	p+	+	-	D, 3 mos
20	73/M	Base of tongue and larynx	Dysphagia, 2 mos	medium to large (A+, N+)	p+	-	NA	-	-	-	+	+	+	+	p+	NA	+	-	D, 6 mos
21	66/M	Periorbital soft tissue	Orbital cellulitis, 2 wks	medium to large (A+, N+)	-	-	p+	-	-	-	+	+	+	+	p+	+	+	-	D, 3 mos
22	56/M	Periorbital soft tissue	Blurred vision and headache, 2 mos	medium to large (A+, N+)	+	-	-	p+	-	-	+	+	p+	p+	+	p+	+	-	D, 10 mos

* Please see the abbreviations below

For "basic morphology": Large: predominantly (>75%) large cells; Medium to large: mixture of medium-sized to large cells (≥25% each); Medium: predominantly (>75%) medium-sized cells; Small to medium: mixture of small to medium-sized cells (≥25% each); A+: presence of angioinvasion; A-: absence of angioinvasion; N+: presence of tissue necrosis; N-: absence of tissue necrosis

For immunophenotype: GB: granzyme B; PF: perforin; + (mostly positive): positive on lymphoma cells >50%; p+ (partially positive): 10-50% positive; p- (probably negative): <10% staining; - (negative): clearly negative; NA: not available

For TCR gene (PCR -based TCR gene rearrangement analysis); - (negative): no clonal band on polyacrylamide gel electrophoresis and no dominant peak on fluorescence capillary electrophoresis; I: inadequate DNA quality for PCR

For clinical course: A: alive; D: death