Table 4.
Summary of immunohistochemical results of the 22 cases of extranodal NK/T-cell lymphoma, nasal type
| Marker | Total cases | Mostly positive | Partially positive | Overall positivity | Probably negative | Clearly negative | Overall negativity |
|---|---|---|---|---|---|---|---|
| CD3 | 22 | 15 (68%) | 5 (23%) | 20 (91%) | 0 | 2 (9%) | 2 (9%) |
| CD20 | 22 | 0 | 0 | 0 | 0 | 22 (100%) | 22 (100%) |
| CD5 | 22 | 0 | 2 (9%) | 2 (9%) | 0 | 20 (91%) | 20 (91%) |
| CD7 | 19 | 5 (26%) | 1 (5%) | 6 (32%) | 1 (5%) | 12 (63%) | 13 (68%) |
| CD4 | 22 | 0 | 3 (14%) | 3 (14%) | 0 | 19 (86%) | 19 (86%) |
| CD8 | 22 | 0 | 0 | 0 | 0 | 22 (100%) | 22 (100%) |
| βF1 | 22 | 0 | 0 | 0 | 0 | 22 (100%) | 22 (100%) |
| CD56 | 22 | 15 (68%) | 3 (14%) | 18 (82%) | 1 (5%) | 3 (14%) | 4 (18%) |
| CD57 | 21 | 0 | 0 | 0 | 0 | 21 (100%) | 21 (100%) |
| TIA-1 | 22 | 22 (100%) | 0 | 22 (100%) | 0 | 0 | 0 |
| Granzyme B | 22 | 13 (59%) | 8 (36%) | 21 (95%) | 1 (5%) | 0 | 1 (5%) |
| Perforin | 22 | 14 (64%) | 5 (23%) | 19 (86%) | 2 (9%) | 1 (5%) | 3 (14%) |
| CD45 | 18 | 8 (44%) | 7 (39%) | 15 (83%) | 0 | 3 (17%) | 3 (17%) |
| CD43 | 22 | 20 (91%) | 2 (9%) | 22 (100%) | 0 | 0 | 0 |
| CD30 | 20 | 10 (50%) | 5 (25%) | 15 (75%) | 0 | 5 (25%) | 5 (25%) |
| ALK | 18 | 0 | 0 | 0 | 0 | 18 (100%) | 18 (100%) |
| OCT2 | 20 | 1 (5%) | 4 (20%) | 5 (25%) | 3 (15%) | 12 (60%) | 15 (75%) |
| IRF4/MUM1 | 15 | 1 (7%) | 4 (27%) | 5 (33%) | 0 | 10 (67%) | 10 (67%) |
Mostly positive = definitely positive on lymphoma cells >50%
Partially positive = 10-50% positive staining
Overall positive = sum of mostly and partially positive results
Probably negative = <10% staining on presumptive lymphoma cells
Clearly negative = clearly negative
Overall negative = sum of probably negative and clearly negative results