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Early S-phase replication appears focal using other methods to denature DNA. (A) Early S-phase BrdU incorporation sites (green) were compared using different methods to denature DNA. Using either heat exposure or base denaturation, early S-phase replication patterns appear focal. (B) Quantitation of replication patterns. Later in S-phase, denaturation by NaOH or heat yields a distributed pattern similar to that generated by DNaseI.
