Table 2.

FA, parallel diffusivity (λ_∥), and perpendicular diffusivity (λ_⊥) measured in the caudal corpus callosum of cuprizone treated mice and the standard deviations of the measurements at several time points using in vivo and ex vivo DTI.

Time (weeks)	in vivo DTI (% change w.r.t. baseline)				ex vivo DTI (% change w.r.t. baseline)
	Brain volume (mm3)	FA	λ∥ (×10-3 mm2/s)	λ⊥ (×10-3 mm2/s)	Brain volume (mm3)	FA	λ∥ (×10-3 mm2/s)	λ⊥ (×10-3 mm2/s)
0 (baseline)	431.3 ± 13.3	0.65 ± 0.10	1.14 ± 0.08	0.32 ± 0.08	445.0 ± 7.1	0.66 ± 0.03	0.45 ± 0.12†	0.13 ± 0.03†
4	422.2 ± 3.6	0.57 ± 0.13 (90%)	0.87 ± 0.19* (76%)	0.37 ± 0.15 (116%)	438.1 ± 10.2	0.43 ± 0.02* (65%)	0.49 ± 0.05† (101%)	0.24 ± 0.03*† (184%)
6	426.3 ± 13.8	0.55 ± 0.04 (87%)	1.10 ± 0.09 (96%)	0.46 ± 0.06* (144%)	439.0 ± 8.4	0.40 ± 0.02*† (61%)	0.48 ± 0.05† (107%)	0.26 ± 0.03*† (200%)
8	435.8 ± 5.6	0.53 ± 0.09 (84%)	1.20 ± 0.09 (105%)	0.52 ± 0.06* (162%)	442.6 ± 9.2	0.44 ± 0.03* (66%)	0.42 ± 0.02† (93%)	0.20 ± 0.02*† (154%)
12	429.9 ± 15.1	0.58 ± 0.04 (89%)	1.06 ± 0.11 (93%)	0.39 ± 0.07 (122%)	433.3 ± 12.9	0.66 ± 0.03 (100%)	0.50 ± 0.06† (111%)	0.16± 0.03† (123%)

^*indicates the value is significant different from the baseline value (p < 0.05)

^†indicates the ex vivo measurement is significant different from corresponding in vivo measurement.