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Co-localization of U1 and U2 snRNAs in the nucleoplasm of living cells imaged using peptide-linked molecular beacons. Shown in (a) & (b) are respectively images of fluorescence signal from U1 and U2 snRNAs in the same living cell. (c) The overlay of the images in (a) and (b) indicating the co-localization of U1 and U2 snRNAs at discrete foci in nucleoplasm. In addition to the U1–U2 co-localized foci, U1 snRNAs can be observed at other foci in the nucleoplasm.
