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. Author manuscript; available in PMC: 2011 Sep 11.
Published in final edited form as: Bioconjug Chem. 2008 Nov 19;19(11):2205–2211. doi: 10.1021/bc800322a

Figure 6.

Figure 6

Fluorescence In-situ hybridization (FISH) images of the U3 localization and U1–U2 co-localization in the nuclei of fixed cells. (a) FISH image of the U3 snoRNA in a fixed cell indicating that most of the signal was in the nucleolus, consistent with the live-cell results. Shown in (b) & (c) are respectively FISH images of the U1 and U2 snRNAs localized at discrete foci in the nucleoplasm of the same fixed cell, in good agreement with that observed in live cells. (d) Overlay of the images in (b) and (c) shows the co-localization of U1 and U2 snRNAs in the nucleus of a fixed cell, confirming that observed in live cells.