. Author manuscript; available in PMC: 2012 Dec 15.

Published in final edited form as: Cancer. 2011 Jun 3;117(24):5548–5559. doi: 10.1002/cncr.26216

Table 5.

Comparison of toxicities of trials utilizing whole brain RT compared with toxicity of RT combined with continuously dosed 37.5 mg sunitinib

	WBRT + Sunitinib	RTOG 9508³⁸	RTOG 0118³⁶	Motexafin Gadolinium³⁹	Efaproxiral³⁷
n	9	167	93	208	250
Grade 1–2 acute tox	40%	62%	66%	NR	NR
Grade 3 acute tox	47%	0%	27%	NR	NR
Grade 4 acute tox	0%	0%	5%	NR	11%
Grade 5 acute tox	13%	0%	2%	NR	NR
All grade nausea	27%	NR	NR	24%	NR
All grade diarrhea	13%	NR	NR	2%	NR
All grade paresthesia	13%	NR	NR	11%	NR
All grade pain	27%	NR	NR	8%	NR
All grade rash	13%	NR	NR	14%	NR
All grade tachycardia	0%	NR	NR	2%	NR
All grade peripheral edema	0%	NR	NR	11%	NR
Hematologic grade 3+	20%	NR	NR	NR	NR
Neurologic-grade 3+	20%	NR	12%	NR	3%
GI- grade 3+	0%	NR	6%	NR	6%
Nausea grade 3+	0%	NR	NR	NR	2%
Vomiting grade 3+	0%	NR	NR	NR	2%
Constipation grade 3+	0%	NR	NR	NR	2%
Vascular- grade 3+	13%	NR	4%	NR	NR
Constitutional-grade 3+	13%	NR	5%	NR	NR
Metabolic- grade 3+	13%	NR	3%	NR	NR