Figure 4. Ganglioside Binding Pocket of HCR/A overlay with HCR/D-SA.
HCR/D-SA (blue) includes conserved internal Phe1280 and Trp1282 (grey), and corresponding residues that represent the Ganglioside Binding Pocket of HCR/A (green). Enlarged views of the Ganglioside Binding Pocket of HCR/A (lower) and the corresponding region of HCR/D-SA (upper) are shown. Residues that contribute to ganglioside binding of HCR/A (Glu1203, His1253, Ser1264, Trp1266 and Tyr1267) and corresponding residues within HCR/D-SA are shown. Reproduced from [62] with permission.