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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: FEBS J. 2011 May 31;278(23):4486–4496. doi: 10.1111/j.1742-4658.2011.08166.x

Figure 5. Ganglioside Binding Loops of HCR/C, HCR/D, and HCR/D-SA overlay with HCR/A and HCR/B.

Figure 5

HCR/D-SA (blue, upper) includes conserved Phe1280 and Trp1282 (black), and the Ganglioside Binding Loop (GBL) is enlarged, rotated, (lower) and aligned with the structurally analogous β-hairpin loops of BoNT/A (purple), /B (orange), /C (red), /D (green). HCR/C and /D-SA loops. Note, BoNT/B has an extended β-hairpin loop like HCR/C, HCR/D, and HCR/D-SA, but lacks a tryptophan residue. BoNT/A, in contrast, does not have an extended β-hairpin loop. Reproduced from [62] with permission.