Table 5.
DAVID functional enrichment analysis on list of 131 downregulated mRNA
| Term | Count | Fold | PValue | Genes |
|---|---|---|---|---|
| fatty acid biosynthetic process | 6 | 9.8 | 0.0003 | FAR1, PLP1, ELOVL5, ELOVL4, SCD, ELOVL7 |
| lipid biosynthetic process | 9 | 3.6 | 0.0034 | FAR1, PLP1, ELOVL5, SPTLC2, ELOVL4, LASS2, SCD, ELOVL7, SGMS1 |
| cytoskeleton organization | 10 | 3.0 | 0.0064 | CDC42, FERMT2, LMO7, ABI2, TNKS, CNP, CAPN3, DST, SPAST, SGCB |
| cell cycle arrest | 5 | 6.3 | 0.0081 | KHDRBS1, CDKN1B, DST, TP53INP1, TGFB2 |
| fatty acid metabolic process | 6 | 3.9 | 0.0183 | FAR1, PLP1, ELOVL5, ELOVL4, SCD, ELOVL7 |
| sphingolipid metabolic process | 4 | 6.9 | 0.0200 | TEX2, SPTLC2, LASS2, SGMS1 |
| cell death | 12 | 2.2 | 0.0221 | SGK1, PLP1, CDKN1B, SPG20, RYBP, BIRC6, RIPK2, SGMS1, DIDO1, SPAST, TP53INP1, TGFB2 |
| ensheathment of axons in the central nervous system | 2 | 85.9 | 0.0229 | PLP1, C11ORF9 |
| myelination in the central nervous system | 2 | 85.9 | 0.0229 | PLP1, C11ORF9 |
| cell projection organization | 8 | 2.8 | 0.0233 | ALCAM, CDC42, CCDC88A, ULK2, ABI2, RDX, CNP, DST |
| sphingolipid biosynthetic process | 3 | 12.5 | 0.0235 | SPTLC2, LASS2, SGMS1 |
| membrane lipid metabolic process | 4 | 6.4 | 0.0244 | TEX2, SPTLC2, LASS2, SGMS1 |
| regulation of organelle organization | 6 | 3.6 | 0.0260 | CDC42, CDKN1B, CCDC88A, RDX, TNKS, DST |
| actin cytoskeleton organization | 6 | 3.4 | 0.0302 | CDC42, FERMT2, LMO7, ABI2, CAPN3, DST |
| Sphingolipid metabolism | 3 | 8.9 | 0.0425 | SPTLC2, PPAP2C, SGMS1 |
| phosphorylation | 12 | 1.9 | 0.0432 | SRPK2, SGK1, ULK2, PIK3C2B, AAK1, GAB1, ABI2, RIPK2, TNKS, CDK7, MON2, TGFB2 |