. Author manuscript; available in PMC: 2012 Nov 1.

Published in final edited form as: Int J Radiat Oncol Biol Phys. 2011 May 5;81(3):e101–e109. doi: 10.1016/j.ijrobp.2011.01.013

Table 3.

Proportional Hazards Regression Models for Local Regional Failure

	Gender (Male vs. Female[RL¹])		Marital Status (Unpartnered vs. Partnered[RL¹])		Race (Non-White vs. White[RL¹])

Treatment Arm	Adjusted Hazard Ratio² (95% CI¹)	p-value	Adjusted Hazard Ratio² (95% CI¹)	p-value	Adjusted Hazard Ratio² (95% CI¹)	p-value
9003: Arm 1 – SFX	0.97 (0.68, 1.36)	0.84	1.22 (0.89, 1.67)	0.21	1.51 (1.10, 2.09)	0.01
9003: Arm 2 – HFX	0.97 (0.62, 1.51)	0.88	1.28 (0.90, 1.82)	0.17	0.98 (0.67, 1.42)	0.90
9003: Arm 3 – AHFX-S	1.28 (0.83, 1.97)	0.27	1.09 (0.79, 1.50)	0.60	1.20 (0.85, 1.68)	0.30
9003: Arm 4 – AFX-C	1.21 (0.76, 1.93)	0.41	1.17 (0.83, 1.64)	0.37	1.59 (0.76, 1.59)	0.63
9111: Arm 1 – I+RT	0.79 (0.48, 1.31)	0.36	1.34 (0.86, 2.09)	0.20	1.40 (0.87, 2.25)	0.16
9111: Arm 2 – CRT	2.56 (0.998, 6.59)	0.052	1.31 (0.76, 2.27)	0.34	1.51 (0.85, 2.69)	0.16
9111: Arm 3 – RT Alone	1.57 (0.87, 2.82)	0.13	0.93 (0.61, 1.44)	0.75	1.18 (0.75, 1.87)	0.48
9703: Arm 1 – Cispl/5-FU	0.94 (0.45, 1.97)	0.86	1.84 (0.95, 3.55)	0.07	1.25 (0.59, 2.67)	0.57
9703: Arm 2 – Hydroxy/5-FU	4.25 (0.995, 18.17)	0.052	0.89 (0.48, 1.63)	0.70	1.03 (0.52, 2.07)	0.93
9703: Arm 3 – Cispl/Taxol	0.74 (0.32, 1.70)	0.48	1.24 (0.60, 2.58)	0.56	0.98 (0.44, 2.17)	0.96

	Chi Square T.S. (Q) = 11.931		Chi Square T.S. (Q) = 4.662		Chi Square T.S. (Q) = 4.772
	p-value = 0.96		p-value = 0.54		p-value = 0.56

Pooled HR³	1.10 (0.93, 1.30)	--	1.19 (1.04, 1.35)	--	1.22 (1.06, 1.41)	--

CI = Confidence Interval; RL = Reference Level

Adjusted for: T-stage (RL: T1-T3), N-stage (RL: N0-N1-N2a), KPS (RL: 60–80), primary site (RL: oropharynx; 9003 and 9703 only), and age (continuous).

This is a pooled estimate.