Table 7.
Unadjusted Proportional Hazards Regression Models for Local-Regional Failure
| Primary Site (Others vs. Oropharynx [RL1]) | T-Stage (T4 vs. T1-3 [RL1]) | |||
|---|---|---|---|---|
| Treatment Arm | Unadjusted Hazard Ratio (95% CI1) | p-value | Unadjusted Hazard Ratio (95% CI1) | p-value |
| 9003: Arm 1 – SFX | 1.27 (0.94, 1.72) | 0.11 | 2.04 (1.50, 2.78) | <0.0001 |
| 9003: Arm 2 – HFX | 1.00 (0.71, 1.40) | 0.99 | 2.46 (1.76, 3.44) | <0.0001 |
| 9003: Arm 3 – AHFX-S | 1.09 (0.80, 1.49) | 0.59 | 1.88 (1.37, 2.59) | 0.0001 |
| 9003: Arm 4 – AFX-C | 1.14 (0.81, 1.59) | 0.45 | 2.12 (1.52, 2.95) | <0.0001 |
| 9111: Arm 1 – I+RT | -- | -- | 0.35 (0.11, 1.16) | 0.09 |
| 9111: Arm 2 – CRT | -- | -- | 1.26 (0.52, 3.02) | 0.61 |
| 9111: Arm 3 – RT Alone | -- | -- | 1.51 (0.70, 3.25) | 0.29 |
| 9703: Arm 1 – Cispl/5-FU | 1.40 (0.75, 2.60) | 0.29 | 1.97 (1.06, 3.68) | 0.03 |
| 9703: Arm 2 – Hydroxy/5-FU | 0.96 (0.51, 1.78) | 0.89 | 2.16 (1.17, 3.97) | 0.01 |
| 9703: Arm 3 – Cispl/Taxol | 1.43 (0.72, 2.87) | 0.31 | 2.59 (1.31, 5.12) | 0.007 |
|
| ||||
| Chi Square T.S. (Q) = 2.325 | Chi Square T.S. (Q) = 11.944 | |||
| p-value = 0.20 | p-value = 0.96 | |||
|
| ||||
| Pooled HR2 | 1.14 (0.99, 1.33) | -- | 2.02 (1.75, 2.33) | -- |
1
CI = Confidence Interval; RL = Reference Level
2
This is a pooled estimate.