Table 9.
Adjusted Proportional Hazards Regression Models for Local-Regional Failure
| Primary Site (Others vs. Oropharynx [RL1]) | T-Stage (T4 vs. T1-3 [RL1]) | |||
|---|---|---|---|---|
| Treatment Arm | Unadjusted Hazard Ratio2 (95% CI1) | p-value | Unadjusted Hazard Ratio2 (95% CI1) | p-value |
| 9003: Arm 1 – SFX | 1.24 (0.92, 1.67) | 0.16 | 1.80 (1.29, 2.51) | 0.0006 |
| 9003: Arm 2 – HFX | 0.86 (0.61, 1.23) | 0.41 | 2.30 (1.62, 3.27) | <0.0001 |
| 9003: Arm 3 – AHFX-S | 1.02 (0.73, 1.42) | 0.93 | 1.70 (1.22, 2.37) | 0.002 |
| 9003: Arm 4 – AFX-C | 1.15 (0.81, 1.63) | 0.43 | 1.79 (1.25, 2.55) | 0.002 |
| 9111: Arm 1 – I+RT | -- | -- | 0.35 (0.10, 1.19) | 0.10 |
| 9111: Arm 2 – CRT | -- | -- | 1.20 (0.43, 3.32) | 0.73 |
| 9111: Arm 3 – RT Alone | -- | -- | 1.55 (0.70, 3.44) | 0.28 |
| 9703: Arm 1 – Cispl/5-FU | 1.73 (0.84, 3.58) | 0.14 | 2.14 (1.03, 4.43) | 0.04 |
| 9703: Arm 2 – Hydroxy/5-FU | 1.08 (0.56, 2.06) | 0.82 | 1.91 (0.97, 3.74) | 0.06 |
| 9703: Arm 3 – Cispl/Taxol | 1.62 (0.75, 3.50) | 0.23 | 2.52 (1.21, 5.23) | 0.01 |
|
| ||||
| Chi Square T.S. (Q) = 5.134 | Chi Square T.S. (Q) = 10.522 | |||
| p-value = 0.60 | p-value = 0.94 | |||
|
| ||||
| Pooled HR3 | 1.11 (0.95, 1.30) | -- | 1.83 (1.57, 2.13) | -- |
1
CI = Confidence Interval; RL = Reference Level
2
Adjusted for: T-stage (RL: T1-T3), N-stage (RL: N0-N1-N2a), KPS (RL: 60–80), primary site (RL: oropharynx; 9003 and 9703 only), and age (continuous), gender (RL: Female), marital status (RL: partnered), race (RL: white).