Table 2.
Baseline number of OADs | Type of OAD | |||||
---|---|---|---|---|---|---|
Characteristic* | Overall | 0/1 OAD | 2 OADs | MET | SU | MET + SU |
Pooled study† | ||||||
N | 2154 | 1020 | 1134 | 185 | 792 | 1084 |
Age (years) | 58.6 (10.1) | 59.5 (10.6) | 57.9 (9.5) | 52.5 (9.9)‡ | 61.2 (10.1)‡ | 57.9 (9.5)‡ |
Sex (male; %) | 55.6 | 56.0 | 55.3 | 51.9 | 56.4 | 54.9 |
Race (White; %) | 88.3 | 90.7 | 85.8 | 71.9 | 95.6 | 86.1 |
Region (USA; %) | 31.3 | 21.2 | 40.4 | 58.9 | 12.8 | 38.8 |
History of diabetes (years) | 8.9 (6.2) | 8.4 (6.0) | 9.3 (6.4)§ | 6.0 (4.1)‡ | 9.1 (6.2)‡ | 9.3 (6.4)‡ |
Baseline HbA1c (%) | 8.77 (1.05) | 8.87 (1.07) | 8.68 (1.02) | 9.08 (1.28) | 8.84 (1.02) | 8.67 (1.03) |
Baseline FPG (mg/dl) | 198.8 (52.3) | 201.6 (51.6) | 196.2 (52.7) | 214.2 (60.2) | 199.3 (49.4) | 195.8 (52.9) |
Baseline body weight (kg) | 88.5 (17.7) | 86.2 (17.4) | 90.6 (17.7) | 95.4 (19.8) | 84.0 (16.3) | 90.3 (17.5) |
Meta-analysis‖ | ||||||
N | 928 | 271 | 657 | 97 | 135 | 609 |
Age (years) | 57.1 (9.5) | 56.8 (9.7) | 57.3 (9.4) | 53.8 (9.2) | 58.8 (9.4) | 57.2 (9.3) |
Sex (male; %) | 58.6 | 62.4 | 57.1 | 57.7 | 63.0 | 56.3 |
Race (White; %) | 88.2 | 88.6 | 88.1 | 90.0 | 88.9 | 88.5 |
Region (USA; %) | 32.2 | 21.0 | 36.8 | 21.6 | 25.2 | 34.0 |
History of diabetes (years) | 8.3 (5.74) | 6.6 (4.5) | 9.0 (6.0) | 5.8 (3.5) | 7.5 (4.7) | 9.1 (6.1) |
Baseline HbA1c (%) | 8.69 (1.04) | 8.70 (1.11) | 8.68 (1.00) | 8.72 (1.20) | 8.71 (1.08) | 8.67 (1.01) |
Baseline FPG (mg/dl) | 199.7 (51.1) | 195.4 (48.9) | 201.5 (51.9) | 198.2 (54.6) | 194.7 (46.9) | 201.3 (52.3) |
Baseline body weight (kg) | 90.8 (17.9) | 89.9 (17.4) | 91.2 (18.1) | 94.9 (18.9) | 88.0 (16.4) | 90.7 (17.7) |
FPG, fasting plasma glucose; MET, metformin; OAD, oral antidiabetic drug; SU, sulfonylurea.
Data are mean (s.d.) unless otherwise specified.
n = 39 were not on any OAD; n = 71 were on ‘other’.
p < 0.05 for class comparison using an analysis of variance model with study and baseline OAD class as factors.
p < 0.05 versus 0/1 OAD group.
n = 36 were not on any OAD; n = 51 were on ‘other’.