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. Author manuscript; available in PMC: 2012 Aug 23.
Published in final edited form as: Biochemistry. 2011 Jul 28;50(33):7284–7293. doi: 10.1021/bi2007977

Figure 5.

Figure 5

Effect of BDZ-f on the whole-cell current amplitude of the GluA2Qflop receptors obtained from the flow measurement. The inhibition constants were determined from this plot by using eq 6. KI of 3.6 ± 0.2 µM was determined for the closed-channel state (100 µM glutamate, ●); a K̅I of 5.7 ± 0.3 µM was obtained for the open-channel state (3 mM glutamate, ○).