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. Author manuscript; available in PMC: 2012 Sep 2.
Published in final edited form as: J Proteome Res. 2011 Jul 28;10(9):4120–4133. doi: 10.1021/pr200310s

Figure 4.

Figure 4

Genetic background-dependent changes in the urinary excretion of aromatic amino acid metabolites. Lower urinary excretion of 2-hydroxyphenylacetic acid in (A) wild-type and (B) Ppara-null mice on the B6 background. Variation in the urinary excretion of xanthurenic acid in (C) wild-type and (D) Ppara-null mice on the B6 background as well as that in the (E) wild-type and (F) Ppara-null mice on the 129S background. Dotted and solid lines respectively represent the variation in the urinary excretion of the metabolite in control diet and alcoholic diet-treated mice of the respective genotype and background. One-way ANOVA with Bonferroni's correction for multiple comparisons was used to estimate statistical significance of the variation of the metabolites on alcohol-treatment within same background. #, significantly different (P < 0.05) from control mice of same genotype.