(a)

Vaccines tested against L. infantum
Antigen	Source  of  antigen	Vaccine delivery	Animal  model	Outcome	Reference
KMPII, TRYP, LACK, and GP63	L. infantum	DNA vaccine	Dog	No protection	Rodríguez-Cortés et al., 2007 [33]
H2A, H2B, H3, and H4	L. infantum	DNA vaccine	Mouse	No protection	Carrión et al., 2008 [34]
p36 LACK	L. infantum	DNA vaccine + protein expressed in vaccinia virus	Mouse	Protection	Dondji et al., 2005 [35]
p36 LACK	L. infantum	DNA vaccine	Mouse	No protection	Marques-da-Silva et al., 2005 [36]
p36 LACK	L. infantum	DNA vaccine	Mouse	Protection	Gomes et al., 2007 [37]
p36 LACK	L. infantum	DNA vaccine + protein expressed in vaccinia virus	Dog	Protection	Ramiro et al., 2003 [38]
p36 LACK	L. infantum	DNA vaccine + protein expressed in vaccinia virus	Dog	Protection	Ramos et al., 2008 [39]
CPA and CPB	L. infantum	DNA vaccine + recombinant protein	Mouse	Protection	Rafati et al., 2006 [40]
CPA and CPB	L. infantum	DNA vaccine + recombinant protein	Dog	Protection	Rafati et al., 2005 [41]
CTE of CPIII	L. infantum	DNA vaccine + recombinant protein	Mouse	No protection	Rafati et al., 2008 [42]
CPC	L. infantum	DNA vaccine + recombinant protein	Mouse	Protection	Khoshgoo et al., 2008 [43]
LCR1	L. infantum	Recombinant protein	Mouse	Partial protection	Wilson, et al., 1995 [44]
LCR1	L. infantum	Protein expressed in BCG	Mouse	Partial protection	Streit et al., 2000 [45]
PapLe22	L. infantum	DNA vaccine	Hamster	Partial protection	Fragaki et al., 2001 [46]
NH36	L. donovani	DNA vaccine	Mouse	Partial protection	Aguilar-Be et al., 2005 [47]
FML	L. donovani	Protein	Mouse	Partial protection	Aguilar-Be et al., 2005 [47]
FML	L. donovani	Protein	Mouse	Protection	Oliveira-Freitas et al., 2006 [48]
Q protein	L. infantum	Recombinant fusion protein of Lip2a, Lip2b, P0, and H2A + BCG	Dog	Protection	Molano et al., 2003 [49]
Q protein	L. infantum	Recombinant fusion protein of Lip2a, Lip2b, P0, and H2A + BCG	Mouse	Partial protection	Parody et al., 2004 [50]
A2	L. donovani	Recombinant protein	Dog	Partial protection	Fernandes et al., 2008 [51]
A2 and NH	L. donovani	DNA vaccine	Mouse	Partial protection	Zanin et al., 2007 [52]
LiESAp	L. infantum	Native protein	Dog	Protection	Lemesre et al., 2005 [53] and 2007 [54]
LiESAp	L. infantum	Native protein	Dog	Protection	Bourdoiseau et al., 2009 [29]
Leish-111f	L. major	Recombinant polyprotein of TSA, LmSTI1, and LeIF	Dog	No protection	Gradoni et al., 2005 [55]
Leish-111f	L. major	Recombinant polyprotein of TSA, LmSTI1, and LeIF formulated in MPL-SE	Dog	Protection	Coler et al., 2007 [56]
Leish-111f	L. major	Recombinant polyprotein of TSA, LmSTI1, and LeIF formulated in MPL-SE	Dog	Protection	Trigo et al., 2010 [57]

CP: cysteine proteinase; CTE: C-terminal extension; BCG: Mycobacterium bovis bacillus Calmette-Guerin; SLA: soluble leishmanial antigens; FML: fucose-mannose ligand; LiESAp: Leishmania infantum excreted-secreted antigen purified; LPG: lipophosphoglycan.