Vaccines tested against L. infantum | |||||
---|---|---|---|---|---|
Antigen | Source of antigen | Vaccine delivery | Animal model | Outcome | Reference |
KMPII, TRYP, LACK, and GP63 | L. infantum | DNA vaccine | Dog | No protection | Rodríguez-Cortés et al., 2007 [33] |
H2A, H2B, H3, and H4 | L. infantum | DNA vaccine | Mouse | No protection | Carrión et al., 2008 [34] |
p36 LACK | L. infantum | DNA vaccine + protein expressed in vaccinia virus | Mouse | Protection | Dondji et al., 2005 [35] |
p36 LACK | L. infantum | DNA vaccine | Mouse | No protection | Marques-da-Silva et al., 2005 [36] |
p36 LACK | L. infantum | DNA vaccine | Mouse | Protection | Gomes et al., 2007 [37] |
p36 LACK | L. infantum | DNA vaccine + protein expressed in vaccinia virus | Dog | Protection | Ramiro et al., 2003 [38] |
p36 LACK | L. infantum | DNA vaccine + protein expressed in vaccinia virus | Dog | Protection | Ramos et al., 2008 [39] |
CPA and CPB | L. infantum | DNA vaccine + recombinant protein | Mouse | Protection | Rafati et al., 2006 [40] |
CPA and CPB | L. infantum | DNA vaccine + recombinant protein | Dog | Protection | Rafati et al., 2005 [41] |
CTE of CPIII | L. infantum | DNA vaccine + recombinant protein | Mouse | No protection | Rafati et al., 2008 [42] |
CPC | L. infantum | DNA vaccine + recombinant protein | Mouse | Protection | Khoshgoo et al., 2008 [43] |
LCR1 | L. infantum | Recombinant protein | Mouse | Partial protection | Wilson, et al., 1995 [44] |
LCR1 | L. infantum | Protein expressed in BCG | Mouse | Partial protection | Streit et al., 2000 [45] |
PapLe22 | L. infantum | DNA vaccine | Hamster | Partial protection | Fragaki et al., 2001 [46] |
NH36 | L. donovani | DNA vaccine | Mouse | Partial protection | Aguilar-Be et al., 2005 [47] |
FML | L. donovani | Protein | Mouse | Partial protection | Aguilar-Be et al., 2005 [47] |
FML | L. donovani | Protein | Mouse | Protection | Oliveira-Freitas et al., 2006 [48] |
Q protein | L. infantum | Recombinant fusion protein of Lip2a, Lip2b, P0, and H2A + BCG | Dog | Protection | Molano et al., 2003 [49] |
Q protein | L. infantum | Recombinant fusion protein of Lip2a, Lip2b, P0, and H2A + BCG | Mouse | Partial protection | Parody et al., 2004 [50] |
A2 | L. donovani | Recombinant protein | Dog | Partial protection | Fernandes et al., 2008 [51] |
A2 and NH | L. donovani | DNA vaccine | Mouse | Partial protection | Zanin et al., 2007 [52] |
LiESAp | L. infantum | Native protein | Dog | Protection | Lemesre et al., 2005 [53] and 2007 [54] |
LiESAp | L. infantum | Native protein | Dog | Protection | Bourdoiseau et al., 2009 [29] |
Leish-111f | L. major | Recombinant polyprotein of TSA, LmSTI1, and LeIF | Dog | No protection | Gradoni et al., 2005 [55] |
Leish-111f | L. major | Recombinant polyprotein of TSA, LmSTI1, and LeIF formulated in MPL-SE | Dog | Protection | Coler et al., 2007 [56] |
Leish-111f | L. major | Recombinant polyprotein of TSA, LmSTI1, and LeIF formulated in MPL-SE | Dog | Protection | Trigo et al., 2010 [57] |
CP: cysteine proteinase; CTE: C-terminal extension; BCG: Mycobacterium bovis bacillus Calmette-Guerin; SLA: soluble leishmanial antigens; FML: fucose-mannose ligand; LiESAp: Leishmania infantum excreted-secreted antigen purified; LPG: lipophosphoglycan.