(b)

Vaccines tested against L. donovani
Antigen	Source of antigen	Vaccine delivery	Animal model	Outcome	Reference
p36 LACK	Multiple species	DNA vaccine	Mouse	No protection	Melby et al., 2001 [58]
dp72	L. donovani	Native protein antigen	Mouse	Partial protection	Jaffe et al., 1990 [59]
A2	L. donovani	Recombinant protein	Mouse	Protection	Ghosh et al., 2001 [60]
A2	L. donovani	DNA vaccine	Mouse	Protection	Ghosh et al., 2001 [61]
HASPB1	L. donovani	Recombinant protein	Mouse	Protection	Stager et al., 2000 [8]
ORFF	L. donovani	Recombinant protein	Mouse	Partial protection	Tewary et al., 2004 [62]
ORFF	L. donovani	DNA vaccine + recombinant protein	Mouse	Partial protection	Tewary et al., 2005 [63]
ORFF	L. donovani	DNA vaccine	Mouse	Partial protection	Sukumaran et al., 2003 [64]
KMP-11	L. donovani	DNA vaccine	Hamster	Protection	Basu et al., 2005 [65]
KMP-11	L. donovani	DNA vaccine	Mouse	Partial protection	Bhaumik et al., 2009 [66]
gp36	L. major	Recombinant protein expressed in bacilli	Mouse	Partial protection	McSorely et al., 1997 [67]
gp36	L. donovani	Native protein in cationic liposomes	Mouse	Partial protection	Bhowmick et al., 2008 [68]
SLA	L. donovani	Native proteins in cationic liposomes	Mouse	Protection	Bhowmick et al., 2007 [69]
SLA	L. donovani	Native proteins	Mouse	Protection	Tewary et al., 2004 [70]
LD9, LD72, LD51, LD31	L. donovani	Native proteins in cationic liposomes	Mouse	Protection	Bhowmick and Ali, 2009 [71]
Leishmanial antigens	L. donovani	Native proteins in liposomes	Mouse	Protection	Mazumdar et al., 2004 [72]
F14	L. donovani	Recombinant protein	Hamster	Partial protection	Bhardwaj et al., 2009 [73]
γ-GCS	L. donovani	DNA vaccine	Mouse	Partial protection	Carter et al., 2007 [74]
FML	L. donovani	Native protein	Mouse	Partial protection	Palanik-de-Sousa et al., 1994 [75]
FML	L. donovani	Native protein	Mouse	Partial protection	Santos et al., 1999 [76]
FML	L. donovani	Formulation with QuilA saponin	Dog	Protection	Borja-Cabrera et al., 2002 [77]
Leishmune (FML)	L. donovani	Recombinant protein	Dog	Partial protection	Saraiva et al., 2006 [78]
Leishmune (FML)	L. donovani	Recombinant protein	Dog	Protection	Nogueira et al., 2005 [79]
H2A, H2B, H3, H4 and LACK	L. donovani	Multiunit DNA vaccine	Dog	Partial protection	Saldarriaga et al., 2006 [80]
LPG	L. donovani	Purified glycolipid + BCG	Hamster and mouse	No protection	Tonui et al., 2003 [81]

CP: cysteine proteinase; CTE: C-terminal extension; BCG: Mycobacterium bovis bacillus Calmette-Guerin; SLA: soluble leishmanial antigens; FML: fucose-mannose ligand; LiESAp: Leishmania infantum excreted-secreted antigen purified; LPG: lipophosphoglycan.