Table 2.

Association between circulating NT-proBNP, testosterone and sex hormone-binding globulin

	Men		Women
Association with log NT-proBNP	Beta* (SE)	P value	Beta* (SE)	P value
Entire sample Single variable
Log free testosterone	−0.30 (0.11)	0.007	−0.54 (0.05)	<0.0001
Log sex hormone-binding globulin	0.23 (0.03)	<0.0001	0.23 (0.02)	<0.0001
Entire sample Multivariable†
Log free testosterone	−0.03 (0.11)	0.78	−0.47 (0.06)	<0.0001
Log sex hormone-binding globulin	0.12 (0.03)	<0.0001	0.25 (0.02)	<0.0001
Non-diabetics only Multivariable‡
Log free testosterone	−0.05 (0.12)	0.65	−0.45 (0.06)	<0.0001
Log sex hormone-binding globulin	0.13 (0.03)	0.0001	0.24 (0.02)	<0.0001

^*Beta coefficients represent the mean change in log NT-proBNP per 1 SD difference in log free testosterone or log sex hormone-binding globulin; For single variable analyses, N=1880 in men (both models); 2144 in women (model containing log free testosterone); and 2147 in women (model containing log sex hormone-binding globulin).

^†Adjusted for age, body mass index, systolic blood pressure, diastolic blood pressure, serum creatinine, antihypertensive medications, diabetes mellitus, and smoking; N=1871 in men (both models); 2123 in women (model containing log free testosterone); and 2126 in women (model containing log sex hormone-binding globulin).

^‡Adjusted for age, body mass index, systolic blood pressure, diastolic blood pressure, serum creatinine, antihypertensive medications, smoking and homeostatic model assessment of insulin resistance; N=1650 in men (both models); 1857 in women (model containing log free testosterone); and 1859 in women (model containing log sex hormone-binding globulin).