Table 3.
Multivariable models assessing the association between sex/hormone status, androgens and NT-proBNP concentrations
| Model without FT | Model with FT | |||
|---|---|---|---|---|
| Association with log NT-proBNP | Beta* (SE) | P value | Beta* (SE) | P value |
| Entire sample (N=3484) | ||||
| Men | −1.12 (0.05) | <0.0001 | −0.51 (0.14) | 0.0004 |
| Postmenopausal women without HRT | −0.46 (0.09) | <0.0001 | −0.35 (0.09) | 0.0001 |
| Premenopausal women without HC | −0.25 (0.05) | <0.0001 | −0.14 (0.05) | 0.008 |
| Postmenopausal women with HRT | −0.34 (0.14) | 0.015 | −0.24 (0.14) | 0.083 |
| Premenopausal women with HC | Referent | Referent | Referent | Referent |
| Log FT | - | - | −0.27 (0.06) | <0.0001 |
|
| ||||
| Women only (N=1613) | ||||
| Postmenopausal women without HRT | −0.35 (0.09) | 0.0001 | −0.17 (0.10) | 0.073 |
| Premenopausal women without HC | −0.22 (0.05) | <0.0001 | −0.05 (0.06) | 0.385 |
| Postmenopausal women with HRT | −0.25 (0.14) | 0.069 | −0.09 (0.14) | 0.499 |
| Premenopausal women with HC | Referent | Referent | Referent | Referent |
| Log FT | - | - | −0.43 (0.07) | <0.0001 |
FT, free testosterone; HRT, hormone replacement therapy; HC, hormonal contraceptives
*
Beta coefficients represent the mean difference in log NT-proBNP in the corresponding sex/hormone status group compared to premenopausal women receiving HC (referent group), or mean change in log NT-proBNP per 1 SD difference in log FT, adjusted for age, body mass index, systolic blood pressure, diastolic blood pressure, serum creatinine, antihypertensive medications, diabetes mellitus, and smoking