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. Author manuscript; available in PMC: 2012 Aug 31.
Published in final edited form as: J Am Chem Soc. 2011 Aug 4;133(34):13698–13705. doi: 10.1021/ja205458h

Figure 6. Phylogenetic analysis of the TruF / LynF family.

Figure 6

(A) TruF-group proteins cluster according to whether natural products are prenylated (top) or non-prenylated (bottom). Chemical products are shown for each TruF-like protein, where they exist. No TruF-like sequence relatives can be identified outside of cyanobactin gene clusters using either BLAST searching or sequence alignments with other PT family proteins, indicating that this is a novel group of PTs. (B) Actual product structures of prenylagaramide (left) and trunkamide (right) pathways; predicted enzymatic product of lyn pathway (middle) prior to Claisen rearrangement.