Table 1.
Comparison of clinical parameters among cirrhotic patients according to VWF multimer patterns.
| Variables | VWF multimer pattrens | a versus b | a versus c | b versus c | ||
|---|---|---|---|---|---|---|
| Degradeda (n = 15) | Normalb (n = 26) | Unusually largec (n = 8) | ||||
| ADAMTS13 : AC (%) (ELISA) | 47 ± 24 | 44 ± 13 | 26 ± 14 | n.s. | P < .05 | P < .01 |
| VWF : RCo (%) | 110 ± 92 | 196 ± 134 | 216 ± 110 | P < .05 | P < .05 | n.s. |
| Child-Pugh score | 8.6 ± 2.5 | 10.9 ± 2.1 | 12.4 ± 1.7 | P < .01 | P < .005 | n.s. |
| Serum albumin (g/dL) | 3.07 ± 0.54 | 2.85 ± 0.54 | 2.59 ± 0.25 | n.s. | P < .05 | n.s. |
| Cholinesterase (IU/L) | 126 ± 62 | 78 ± 64 | 60 ± 36 | P < .05 | P < .02 | n.s. |
| Total cholesterol (mg/dL) | 142 ± 51 | 93 ± 45 | 88 ± 40 | P < .01 | P < .03 | n.s. |
| Hemoglobin (g/dL) | 11.0 ± 1.7 | 9.3 ± 2.0 | 8.9 ± 1.7 | P < .02 | P < .02 | n.s. |
| Serum creatinine (mg/dL) | 1.06 ± 0.72 | 1.11 ± 0.79 | 2.43 ± 2.16 | n.s. | P < .05 | P < .03 |
| Blood urea nitrogen (mg/dL) | 22 ± 17 | 30 ± 21 | 74 ± 62 | n.s. | P < .01 | P < .01 |
| Blood ammonia (μg/dL) | 87 ± 50 | 100 ± 39 | 144 ± 53 | n.s. | P < .05 | P < .05 |
VWF: von Willebrand factor; ADAMTS13 : AC : ADAMTS13 activity; ELISA : enzyme-linked immunosorbent assay; VWF : RCo: VWF ristocetin cofactor activity; n.s.: not significant. (Partially modified from Uemura et al., [30]).