Figure 1.

IL-10 signal transduction and hypothesized treatment by dual gene therapy. (a) shows multiple possible IL-10 signal transduction pathways. The STAT3 pathway results in an anti-inflammatory response. (b) shows our attempt to enhance IL-10 signaling at two points with the hypothesis that enhanced gene expression of the anti-inflammatory gene set would occur. The gene delivery is indicated by larger font and bolded IL-10 and STAT3. More powerful signal transduction is represented by larger arrows and larger font.