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Cooperation of Rb family inactivation with oncogenic Ras in a nude-mice transformation assay
| MEFs genotype
|
Tumors
|
Number of different clones tested
|
|---|---|---|
| Wild-type | 0/2 | 2 |
| p107−/−;p130−/− | 0/4 | 2 |
| Rb−/− | 0/4 | 2 |
| TKO | 0/6 | 4 |
| p53−/− | 0/2 | 2 |
| H-RasV12-TKOa | 8/10 | 6 |
| H-RasV12;E1A;p53−/−b | 3/3 | 1 |
Each clone was injected one or two times.
Tumors apparent 12–15 d after injection into nude mice.
Tumors apparent 8–10 d after injection into nude mice.
