Table 3. Genotype and allele frequency distribution, and association with stroke susceptibility for the IL6 and MPO SNPs.
| Gene | SNP | Genotype |
Genotype frequency |
OR (95% CI) | Pa | |
|---|---|---|---|---|---|---|
| Controls, n (%) | Cases, n (%) | |||||
| IL6 | rs2069837 | |||||
| A/A | 365 (76.4) | 461 (81.2) | 0.66 (0.50–0.89) | 0.005b | ||
| G/A | 105 (22.0) | 102 (18.0) | ||||
| G/G | 8 (1.7) | 5 (0.9) | ||||
| IL6 | rs2069861 | |||||
| C/C | 442 (91.9) | 497 (86.9) | 1.74 (1.15–2.63) | 0.007b | ||
| T/C | 39 (8.1) | 70 (12.2) | ||||
| T/T | 0 (0.0) | 5 (0.9) | ||||
| MPO | rs8178406 | |||||
| T/T | 151 (31.4) | 221 (38.9) | 0.78 (0.65–0.95) | 0.011b | ||
| T/C | 254 (52.8) | 262 (46.1) | ||||
| C/C | 76 (15.8) | 85 (15.0) | ||||
CI, confidence interval; OR, odds ratio; SNPs, single-nucleotide polymorphisms.
Only associated SNPs are shown. OR>1 indicates increased probability of having a stroke for the carriers of the minor allele.
a
OR (95% CI) and P for the log-additive genetic model after adjustment for significant covariates (gender, history of hypertension, diabetes, and smoking status).
b
Significant result after Bonferroni correction.