Table 4. Gene × gene interaction models obtained using the multifactor-dimensionality reduction (MDR) method in stroke susceptibility.
| Genes |
Best model |
CVC | TBA | P* | |||
|---|---|---|---|---|---|---|---|
| SNP1 | SNP2 | SNP3 | SNP4 | ||||
| IL1B_TNF | rs1143643(IL1B) | rs16944(IL1B) | rs2071590(TNF) | — | 8/10 | 0.517 | 0.487 |
| IL6_TNF | rs10242595(IL6) | rs909253(TNF) | — | — | 10/10 | 0.549 | 0.054 |
| IL6_IL1B | rs2069837(IL6) | rs10242595(IL6) | rs1143643(IL1B) | — | 5/10 | 0.541 | 0.145 |
| MPO_TNF | rs2071590(TNF) | rs8178406(MPO) | — | — | 9/10 | 0.547 | 0.060 |
| IL6_MPO | rs10242595(IL6) | rs8178406(MPO) | — | — | 9/10 | 0.556 | 0.031 |
| MPO_IL1B | rs1143643(IL1B) | rs16944(IL1B) | rs8178406(MPO) | rs4401102(MPO) | 9/10 | 0.538 | 0.160 |
| IL1B_IL6_TNF_MPO | rs10242595(IL6) | rs1143643(IL1B) | rs8178406(MPO) | rs4401102(MPO) | 8/10 | 0.527 | 0.323 |
CVC, cross-validation consistency; SNP, single-nucleotide polymorphism; TBA, testing balanced accuracy.
*
1,000 permutations P.
Bold values are significant results.