Table 1. Concentration of N-acetyl aspartate.
| Control | KA | |
|---|---|---|
| Hippocampal formation | 4.5±0.5 | 3.1±1.0* |
| Entorhinal/piriform cortex | 5.2±0.7 | 2.5±0.8** |
| Neocortex | 6.0±1.1 | 6.4±0.9 |
KA, kainate; MRS, magnetic resonance spectroscopy.
Concentration of NAA (μmol/g brain tissue) was measured by 1H MRS in different brain regions of control and KA-treated rats 2 weeks after saline (control) or KA treatment. For controls and KA, respectively, sample sizes were n=9 and 11 (hippocampal formation), n=3 and 11 (entorhinal/piriform cortex), and n=10 and 6 (neocortex). Data represent means±s.d. P-value using Student's t-test, only given when significantly different from corresponding control group, P<0.05.
*P=0.001 and **P=0.0001.