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. 2011 Apr 15;25(7):1135–1146. doi: 10.1038/leu.2011.50

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Copyright © 2011 Macmillan Publishers Limited

This work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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Induction of proapoptotic pathways after GSI-I treatment. (a) Top: GSI-I treatment leads to PARP and caspase 3 cleavage/activation in Nalm6 and 697 cells but not Tanoue cells. Bottom: time course of caspase 9 and caspase 3 activation in GSI-I-treated 697 cells. (b) Time course of ROS production in 697 cells after addition of 2.5 μ GSI-I. (c) Protection of GSI-induced apoptosis in 697 cells by the caspase inhibitor, Z-VAD or the ROS scavenger, N-acetylcysteine (NAC). (d) Western blotting results show GSI-induced changes in the total AKT, phospho-AKT, phospho-FoxO3a and level of BimEL in lysates from 697, Nalm6 and Tanoue cells.