Table 2. Summary of results in human precursor-B ALL xenograft model.

Mouse number	% Blasts in blood smear	% Blasts in bone marrow aspirate	Liver infiltration	hCD10 in bone marrow
Untreated
1	0	8–11	+	+++
2	0	3–6	++	+
3	4–6	39–44	−	++
4	ND	∼100	+++	+++
5	0–1	2	+	+
6	0	2	−	+
7	51–56	∼100	+++	+++
8	41–43	∼100	+++	+++
9	8–10	41–46	++	+++
10	12–15	39–43	++	++
11	0	0–1	+	+
GSI-I treated
1a	0	0	−	−
2	41–45	∼100	+++	+++
3a	0	0	−	−
4	1–3	6–11	++	+++
5a	0	0	−	−
6	3–6	ND	++	+
7	8–11	ND	++	++
8	19–22	56–58	+++	+++
9a	0	0	−	−
10a	0	0	−	−
11	8–12	44–46	+++	+++
12a	0	0	−	−

Abbreviations: ALL, acute lymphoblastic leukemia; GSI, gamma secretase inhibitor; ND, not done.

^aIn all, 6 of 12 treated mice free of disease after GSI-I treatment.

+, few nodules (1–5).

++, multiple nodules (>5).

+++, large areas infiltrated.