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. 2011 Apr 15;25(7):1135–1146. doi: 10.1038/leu.2011.50

Table 2. Summary of results in human precursor-B ALL xenograft model.

Mouse number % Blasts in blood smear % Blasts in bone marrow aspirate Liver infiltration hCD10 in bone marrow
Untreated
  1 0 8–11 + +++
  2 0 3–6 ++ +
  3 4–6 39–44 ++
  4 ND ∼100 +++ +++
  5 0–1 2 + +
  6 0 2 +
  7 51–56 ∼100 +++ +++
  8 41–43 ∼100 +++ +++
  9 8–10 41–46 ++ +++
 10 12–15 39–43 ++ ++
 11 0 0–1 + +
         
GSI-I treated
  1a 0 0
  2 41–45 ∼100 +++ +++
  3a 0 0
  4 1–3 6–11 ++ +++
  5a 0 0
  6 3–6 ND ++ +
  7 8–11 ND ++ ++
  8 19–22 56–58 +++ +++
  9a 0 0
 10a 0 0
 11 8–12 44–46 +++ +++
 12a 0 0

Abbreviations: ALL, acute lymphoblastic leukemia; GSI, gamma secretase inhibitor; ND, not done.

a

In all, 6 of 12 treated mice free of disease after GSI-I treatment.

+, few nodules (1–5).

++, multiple nodules (>5).

+++, large areas infiltrated.