Table 1. Genes hypermethylated in more than 80% of YST samples analysed by GoldenGate array.
Genes hypermethylated in more than 80% of YST samples, and in <25% of germinoma samples in the methylation array |
APC, ASCL2, BDNF, CCNA1, CD2, CYP1B1, ESR1, HCK, HFE, HLA-F, HOXA9, HPN, HS3ST2, IGF2AS, IRAK3, IRF5, KLK10, LAT, NPY, NTSR1, OSM, PDGFRB, PYCARD, RASSF1, RIPK3, SCGB3A1, SLC22A3, STAT5A, TAL1, TNFSF8, VAV1, WNT1, WNT10B |
Abbreviations: YST=yolk sac tum.
Genes in bold were hypermethylated in all YSTs exhibiting the ‘methylator’ phenotype.