Table 1. Association of cytoplasmic and nuclear MSX2 with histopathological parameters.
|
Cytoplasmic MSX2
|
Nuclear MSX2
|
||||||
|---|---|---|---|---|---|---|---|
| Variable | N | MSX2 negative, N (%) | MSX2 positive, N (%) | P-valuea | MSX2 negative, N (%) | MSX2 positive, N (%) | P-value a |
| T-stage | 189 | 0.030 | 0.655 | ||||
| T1 | 12 (18) | 39 (32) | 24 (26) | 27 (28) | |||
| T2–T4 | 56 (82) | 82 (68) | 70 (74) | 68 (72) | |||
| Clark level | 182 | 0.088 | 0.903 | ||||
| 1–3 | 28 (43) | 67 (58) | 45 (52) | 50 (53) | |||
| 4–5 | 37 (57) | 50 (42) | 42 (48) | 45 (47) | |||
| Subtype | 190 | 0.658 | 0.126 | ||||
| SSM | 19 (28) | 39 (32) | 35 (37) | 23 (24) | |||
| Nodular | 21 (31) | 31 (25) | 22 (23) | 30 (31) | |||
| Other | 27 (40) | 53 (43) | 37 (39) | 43 (45) | |||
| Ulceration | 177 | 0.115 | 0.492 | ||||
| Absent | 41 (64) | 85 (75) | 62 (69) | 64 (74) | |||
| Present | 23 (36) | 28 (25) | 28 (31) | 23 (26) | |||
| Site | 188 | 0.576 | 0.532 | ||||
| Head and neck | 15 (22) | 38 (31) | 22 (23) | 31 (33) | |||
| Trunk | 13 (19) | 20 (17) | 17 (18) | 16 (17) | |||
| Upper limb | 12 (18) | 19 (16) | 17 (18) | 14 (15) | |||
| Lower limb | 28 (41) | 43 (36) | 38 (40) | 33 (35) | |||
Abbreviations: N=number of patients; SSM=superficial spreading melanoma.
a
χ2-test. P-values <0.05 is shown in bold.