Table 2. Cox regression analysis of recurrence-free survival and overall survival (entire cohort).

	Univariate			Multivariatea
Prognostic factor	HR	(95% CI)	P-value	HR	(95% CI)	P-value
Recurrence-free survival
Cytoplasmic MSX2 (positive vs negative, ref)	0.489	0.285–0.840	0.009	0.503	0.284–0.893	0.019
T-stage (T2–T4 vs T1, ref)	7.466	2.689–20.739	<0.001	6.372	1.955–20.767	0.002
Ulceration (positive vs negative, ref)	3.267	1.846–5.781	<0.001	2.653	1.464–4.809	0.001
Overall survival
Cytoplasmic MSX2 (positive vs negative, ref)	0.594	0.348–1.014	0.059	0.653	0.376–1.136	0.132
T-stage (T2–T4 vs T1, ref)	9.696	3.021–31.117	<0.001	10.060	2.419–41.841	0.002
Ulceration (positive vs negative, ref)	3.528	2.021–6.160	<0.001	2.900	1.610–5.223	<0.001

Abbreviations: CI=confidence interval; HR=hazard ratio; ref=referent group.

^aAdjusted for all other variables in the subsection. P-values <0.05 are shown in bold.